Objective: to study the neuropsychological aspects of catamenial epilepsy with clarification of the role of anticonvulsants in the development of cognitive impairment. Material and methods: under supervision were 62 patients with epilepsy (E), which divided into 2 groups: 48 with catamenial epilepsy (CE), 14 with idiopathic epilepsy (IE), mean age 38 ± 15.6 years. Results: in 59.8% of cases, catamenial epilepsy accompanied by cognitive impairment. The form of cognitive impairment depends on the type of seizure. In patients with idiopathic epilepsy, cognitive disorders in the form of moderate and predimentary disorders are more common. Catamenial and idiopathic forms of epilepsy differ in neuropsychological indicators: in patients with idiopathic epilepsy, both short-term and long-term memory suffers, in patients with catamenial epilepsy, short-term memory is more impaired. Conclusions: more distinguished cognitive disturbances noted in patients, taking antivulsants carbamazepine, valproats less in the background of topiramite. Topiramits may be used as a preparation of the choice in the treatment of female epilepsy.