COMPARATIVE CHARACTERISTICS OF THE EFFECTS OF HYPEROSMOLAR THERAPY IN PATIENTS WITH CRANIOCEREBRAL TRAUMA
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Keywords

TBI, brain edema, CPP, SBP, osmolarity, plasma electrolytes

How to Cite

Avakov, V., Ibragimov, N., Murotov, T., & Kenjaev, L. (2019). COMPARATIVE CHARACTERISTICS OF THE EFFECTS OF HYPEROSMOLAR THERAPY IN PATIENTS WITH CRANIOCEREBRAL TRAUMA. Herald of Tashkent Medical Academy, (3 (31), 97-100. Retrieved from http://www.tma-journals.uz/index.php/ttaa/article/view/62

Abstract

Objective: to study the possibility and comparative efficacy of using 15% mannitol solution and hypertensive 3.5% sodium chloride solution in the complex of treatment for patients with TBI. Material and Methods: 30 patients aged 16 to 68 years with various craniocerebral injuries and depression of the level of consciousness from 4 to 11 on the Glasgow coma scale were examined. Results: the infusion of mannitol in this dosage resulted in a reduction in ICP after 30 minutes by 42.3%, and after 120 min it fell below the baseline data by 23.9%. Infusion of a 3.5% solution of NaCl already by the 30th minute resulted in a decrease in ICP by 48.6%, and by the end of 120 minutes ICP remained below the initial data by 35.9%. Conclusions: use of 3.5% NaCI leads to a longer lasting significant increase in CPP and a prolonged decrease in ICP with respect to the 15% mannitol solution. Key

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