THE INFLUENCE OF REAMBISOL ON FUNCTIONAL AND METABOLIC PARAMETERS OF BONE MARROW CELLS AND ERYTHROCYTES IN HEMORRHAGIC SHOCK
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Keywords

hemorrhagic shock, rheosorbilact, reoambrasol, hemocorrectors, bone marrow cells, heme synthesis, lipid peroxidation

How to Cite

Karimov, K., Shevchenko, L., Isroilov, A., & Alimov, T. (2019). THE INFLUENCE OF REAMBISOL ON FUNCTIONAL AND METABOLIC PARAMETERS OF BONE MARROW CELLS AND ERYTHROCYTES IN HEMORRHAGIC SHOCK. Herald of Tashkent Medical Academy, (3 (31), 85-88. Retrieved from http://www.tma-journals.uz/index.php/ttaa/article/view/59

Abstract

Objective: evaluation the effectiveness of rheoambrasol in correcting the functional and metabolic parameters of bone marrow cells and red blood cells on a hemorrhagic shock model. Material and methods: hemorrhagic shock model in 20 rabbits reproduced according to the Wiggers method. Infusion of hemoprotectors carried out at a dose of 40 ml / kg of animal weight. Results: rheosorbilact has a pronounced hemodynamic effect in hemorrhagic shock and in its activity is not inferior to reosorbilact. Preparations, especially rheoambrasol, stabilizes the activity of heme synthesis regulatory enzymes in bone marrow cells, preventing the accumulation of heme synthesis intermediates in erythrocytes, reduces erythrocyte lysis, which is manifested by a decrease in high levels of indirect bilirubin, thereby reducing the risk of anemia. In terms of its antioxidant properties, the studied drug is superior to the well-known hemocorrector rheosorbilact. Conclusions: rheoambrasol in animals with hemorrhagic shock corrects the functional and metabolic parameters of bone marrow cells and erythrocytes.

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