Objective: to evaluate the efficacy of rheoambrasol in correcting endogenous intoxication on the model of heliotrin liver damage (HLD). Material and methods. Experiments were carried out on 80 male rats with an initial body weight of 170-200 g. Acute HLD was induced by a single subcutaneous injection of rats with a solution of heliotrin prepared at a rate of 40 mg per 100 g of body weight. The intact group consisted of 8 rats that were on a normal laboratory diet. Results: a new drug, reambrasol containing the natural metabolite of the Krebs cycle in combination with polysaccharides increases the low activity of the pharmaco-metabolizing function of the lover in case of its heliotrinic damage. It significantly reduces the level of medium-weight molecules and oligopeptides in the plasma and erythrocytes in the rats blood with heliotrin intoxication and its detoxification properties are superior than the reosorbilact. Reaombrasol reliably reduces high indices of toxemia and intoxication in rats with heliotrinic liver damage. Conclusions: on the model of heliotrinic, liver damage reambrosol effectively increases the pharmacological and metabolic function of the liver and reduces the indices of endogenous intoxication.