Objective: assessment of influence of kavergal on the morphological changes in the walls of heart of rabbits after modelling of metabolic syndrome. Material and methods: according to recommendations of Kh.Karimov et al on 12 rabbits reproduced model of metabolic syndrome. Kavergal had been injected in 6 rabbits and another 6 served as comparison group. Results: the metabolic syndrome characterized by lesion of the endocardium, myocardium and epicardium which is manifested myolisis, poly morphonuclear infiltration, dystrophy and vascular changes with the deposition of lipids in them. Pharmacotherapy of heart walls with Kavergal significantly reduces the severity of these changes, there is significant decrease in adipose tissue of the epicardium. Conclusions: is advisable to include in the complex treatment of cardiovascular complications in patients with metabolic syndrome.