Purpose: a comparative study of the molecular mechanisms of the detoxifying effect of the new hepatoprotectors Caergal, Geranil and Catacin on the model of acute liver damage. Material and methods: in 52 mature rats, the males reproduced the model of acute toxic damage reproduced by a single injection of heliotrin in a dose of 200 mg / kg, 8 rats served as an intact group. Results: experimental pharmacotherapy of acute toxic liver damage with new drugs katatsin and geranil reliably shorten the duration of ethanaminal anesthesia, which indicates their beneficial effect on xenobiotic biotransformation processes, and is not inferior in its activity to Karsil. Antihypoxant cavergal had a weak effect. Conclusions: the mechanism of the positive effect of the studied drugs is associated with a decrease in the intensity of lipid peroxidation in the microsomal cytosolic fraction of the liver, an increase in the activity of SOD and catalase, as a result, by restoring the balance in the pro-and antioxidant system.